AC   MF_00456;
DC   Protein; auto
TR   HAMAP; MF_00456; -; 1; level=0
XX
Names: ProB
XX
ID   PROB
DE   RecName: Full=Glutamate 5-kinase;
DE            EC=2.7.2.11;
DE   AltName: Full=Gamma-glutamyl kinase;
DE            Short=GK;
GN   Name=proB;
XX
CC   -!- FUNCTION: Catalyzes the transfer of a phosphate group to glutamate to
CC       form L-glutamate 5-phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-glutamate = ADP + L-glutamyl 5-phosphate;
CC         Xref=Rhea:RHEA:14877, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58274, ChEBI:CHEBI:456216; EC=2.7.2.11;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate
CC       5-semialdehyde from L-glutamate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glutamate 5-kinase family.
XX
DR   Pfam; PF00696; AA_kinase; 1; trigger=no
DR   Pfam; PF01472; PUA; 1; trigger=no
DR   PIRSF; PIRSF000729; GK; 1; trigger=no
DR   PRINTS; PR00474; GLU5KINASE; 1; trigger=no
DR   NCBIfam; TIGR01027; ProB; 1; trigger=no
DR   PROSITE; PS00902; GLUTAMATE_5_KINASE; 1; trigger=no
DR   PROSITE; PS50890; PUA; 0-1; trigger=yes
XX
KW   Amino-acid biosynthesis
KW   ATP-binding
KW   Cytoplasm
KW   Kinase
KW   Nucleotide-binding
KW   Proline biosynthesis
KW   Transferase
XX
GO   GO:0004349; F:glutamate 5-kinase activity
GO   GO:0006561; P:proline biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: PROB_ECOLI (P0A7B5)
FT   BINDING         169..170
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [TS]-D
FT   BINDING         211..217
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [TS]-G-G-[MI]-x-[TS]-K
FT   BINDING         10
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
FT   BINDING         50
FT                   /ligand="substrate"
FT   Optional; Condition: S
FT   BINDING         137
FT                   /ligand="substrate"
FT   Optional; Condition: D
FT   BINDING         149
FT                   /ligand="substrate"
FT   Optional; Condition: N
XX
Size: 245-470;
Related: None;
Template: P0A7B5; P17856; P96488;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACSU, PSET1, RHILO, RHIME
Plasmid: None
Comments: None
XX
# Revision 1.40 2023/06/01
//