AC   MF_00469;
DC   Protein; auto
TR   HAMAP; MF_00469; -; 1; level=0
XX
Names: TrhO
XX
ID   TRHO
DE   RecName: Full=tRNA uridine(34) hydroxylase;
DE            EC=1.14.-.-;
DE   AltName: Full=tRNA hydroxylation protein O;
GN   Name=trhO;
XX
case <OC:Escherichia>
CC   -!- FUNCTION: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U)
CC       modification at position 34 in tRNAs, the first step in 5-
CC       carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate
CC       pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs
CC       under aerobic conditions.
else
CC   -!- FUNCTION: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U)
CC       modification at position 34 in tRNAs.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA
CC         + A + H2O; Xref=Rhea:RHEA:64224, Rhea:RHEA-COMP:11727, Rhea:RHEA-
CC         COMP:13381, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:65315, ChEBI:CHEBI:136877;
CC   -!- SIMILARITY: Belongs to the TrhO family.
XX
DR   Pfam; PF00581; Rhodanese; 1; trigger=no
DR   PROSITE; PS50206; RHODANESE_3; 1; trigger=yes
XX
KW   Oxidoreductase
KW   tRNA processing
XX
GO   GO:0006400; P:tRNA modification
GO   GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
XX
FT   None
XX
Size: 239-367;
Related: None;
Template: P24188;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.27 2020/05/22
//