AC   MF_00473;
DC   Protein; auto
TR   HAMAP; MF_00473; -; 1; level=0
XX
Names: G6P_isomerase
XX
ID   G6PI
case <OC:Bacteria>
DE   RecName: Full=Glucose-6-phosphate isomerase;
DE            Short=GPI;
DE            EC=5.3.1.9;
DE   AltName: Full=Phosphoglucose isomerase;
DE            Short=PGI;
DE   AltName: Full=Phosphohexose isomerase;
DE            Short=PHI;
end case
case <OC:Archaea>
DE   RecName: Full=Probable glucose-6-phosphate isomerase;
DE            Short=GPI;
DE            EC=5.3.1.9;
DE   AltName: Full=Phosphoglucose isomerase;
DE            Short=PGI;
DE   AltName: Full=Phosphohexose isomerase;
DE            Short=PHI;
end case
GN   Name=pgi;
XX
CC   -!- FUNCTION: Catalyzes the reversible isomerization of glucose-6-phosphate
CC       to fructose-6-phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9;
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the GPI family.
XX
DR   Pfam; PF00342; PGI; 1; trigger=no
DR   PRINTS; PR00662; G6PISOMERASE; 1; trigger=no
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1; trigger=no
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1; trigger=no
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1; trigger=no
XX
case <FT:4> or <FT:5> or <FT:6>
KW   Acetylation
end case
KW   Cytoplasm
KW   Isomerase
KW   Gluconeogenesis
KW   Glycolysis
case <FT:7>
KW   Phosphoprotein
end case
XX
GO   GO:0004347; F:glucose-6-phosphate isomerase activity
GO   GO:0006094; P:gluconeogenesis
GO   GO:0006096; P:glycolytic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: G6PI_ECOLI (P0A6T1)
FT   ACT_SITE        355
FT                   /note="Proton donor"
FT   Condition: E
FT   ACT_SITE        386
FT   Condition: H
FT   ACT_SITE        514
FT   Condition: K
case <OC:Escherichia> or <OC:Shigella>
FT   MOD_RES         80
FT                   /note="N6-acetyllysine"
FT   Condition: K
FT   MOD_RES         228
FT                   /note="N6-acetyllysine"
FT   Condition: K
FT   MOD_RES         234
FT                   /note="N6-acetyllysine"
FT   Condition: K
end case
FT   From: G6PI_BACSU (P80860)
case <OC:Bacillaceae>
FT   MOD_RES         38
FT                   /note="Phosphothreonine"
FT   Condition: T
end case
XX
Size: 401-562;
Related: None;
Template: P0A6T1; P0A0T1; P28718; Q9X1A5; P9WN69;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in GEOSE, CHRSD, NEIMA, NEIMB, CUPPJ, RHOJR, STRAW, STRCO, THIDA
Plasmid: None
Comments: None
XX
# Revision 1.44 2021/11/11
//