AC   MF_00476;
DC   Protein; auto
TR   HAMAP; MF_00476; -; 1; level=0
XX
Names: NikR
XX
ID   NIKR
case <OC:Enterobacterales>
DE   RecName: Full=Nickel-responsive regulator;
GN   Name=nikR;
else
DE   RecName: Full=Putative nickel-responsive regulator;
end case
XX
case <OC:Enterobacterales>
CC   -!- FUNCTION: Transcriptional repressor of the nikABCDE operon. Is active
CC       in the presence of excessive concentrations of intracellular nickel.
else
CC   -!- FUNCTION: Transcriptional regulator.
end case
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC       Note=Binds 1 nickel ion per subunit.;
end case
case <OC:Enterobacterales>
CC   -!- SUBUNIT: Homotetramer.
end case
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
XX
DR   Pfam; PF08753; NikR_C; 1; trigger=no
DR   Pfam; PF01402; RHH_1; 1; trigger=no
DR   NCBIfam; TIGR02793; NikR; 1; trigger=no
XX
case <OC:Enterobacterales>
KW   Repressor
end case
KW   Transcription
KW   Transcription regulation
KW   DNA-binding
case <FTGroup:1>
KW   Nickel
KW   Metal-binding
end case
XX
GO   GO:0016151; F:nickel cation binding
GO   GO:0003700; F:DNA-binding transcription factor activity
GO   GO:0006355; P:regulation of DNA-templated transcription
XX
FT   From: NIKR_ECOLI (P0A6Z6)
FT   BINDING         76
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT   Group: 1; Condition: H
FT   BINDING         87
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT   Group: 1; Condition: H
FT   BINDING         89
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT   Group: 1; Condition: H
FT   BINDING         95
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT   Group: 1; Condition: C
XX
Size: 127-148;
Related: None;
Template: P0A6Z6;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in METAC, METMA, METTH
Plasmid: None
Comments: None
XX
# Revision 1.37 2023/06/01
//