AC   MF_00486;
DC   Protein; auto
TR   HAMAP; MF_00486; -; 1; level=0
XX
Names: McH
XX
ID   MCH
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch;
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+).
else
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-
CC       H(4)MPT.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
end case
case <OC:Archaeoglobales>
CC   -!- PATHWAY: Metabolic intermediate metabolism; lactate oxidation.
end case
case <OC:Bacteria>
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC       formaldehyde (H(4)MPT route): step 3/5.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MCH family.
XX
DR   Pfam; PF02289; MCH; 1; trigger=no
DR   NCBIfam; TIGR03120; One_C_mch; 1; trigger=no
XX
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
KW   Methanogenesis
end case
KW   Cytoplasm
KW   One-carbon metabolism
KW   Hydrolase
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GO   GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity
GO   GO:0006730; P:one-carbon metabolic process
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO   GO:0015948; P:methanogenesis
end case
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 311-337;
Related: None;
Template: P94954; O28344; O85014;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.33 2023/06/01
//