AC   MF_00487;
DC   Protein; auto
TR   HAMAP; MF_00487; -; 1; level=0
XX
Names: Malate_dehydrog_3
XX
ID   MDH
DE   RecName: Full=Malate dehydrogenase;
DE            EC=1.1.1.37;
GN   Name=mdh;
XX
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 3 family.
XX
DR   Pfam; PF02866; Ldh_1_C; 1; trigger=no
DR   Pfam; PF00056; Ldh_1_N; 1; trigger=no
DR   PRINTS; PR00086; LLDHDRGNASE; 1; trigger=no
DR   NCBIfam; TIGR01763; MalateDH_bact; 1; trigger=no
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1; trigger=no
XX
KW   NAD
KW   Oxidoreductase
KW   Tricarboxylic acid cycle
case <FTTag:phospho>
KW   Phosphoprotein
end case
XX
GO   GO:0030060; F:L-malate dehydrogenase activity
GO   GO:0006099; P:tricarboxylic acid cycle
XX
FT   From: MDH_CHLAA (P80040)
FT   BINDING         9..14
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G-x(1,2)-G-x-x-G
FT   BINDING         118..120
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [VILT]-[GSNAT]-N
FT   ACT_SITE        175
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: D
FT   BINDING         82
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         88
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         95
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N
FT   BINDING         120
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         151
FT                   /ligand="substrate"
FT   Condition: R
FT   From: MDH_BACSU (P49814)
case <OC:Bacillaceae>
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT   Tag: phospho; Condition: S
end case
XX
Size: 278-335;
Related: MF_00488!; MF_01516; MF_01517;
Template: Q25QU7; P80040; P80039; P61889;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in ANADE, AQUAE, RHOPB
Plasmid: None
Comments: Also called LDH-like MDH
XX
# Revision 1.37 2023/06/01
//