AC   MF_00493;
DC   Protein; auto
TR   HAMAP; MF_00493; -; 1; level=0
XX
Names: Transaldolase_2
XX
ID   TAL
DE   RecName: Full=Transaldolase;
DE            EC=2.2.1.2;
GN   Name=tal;
XX
CC   -!- FUNCTION: Transaldolase involved in the non-oxidative phase in the
CC       pentose phosphate pathway. Catalyzes the reversible conversion of
CC       sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into
CC       erythrose-4-phosphate and beta-D-fructose 6-phosphate. Transaldolase is
CC       important for the balance of metabolites in the pentose-phosphate
CC       pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate =
CC         D-erythrose 4-phosphate + beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:17053, ChEBI:CHEBI:16897, ChEBI:CHEBI:57483,
CC         ChEBI:CHEBI:57634, ChEBI:CHEBI:59776; EC=2.2.1.2;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-
CC       ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage):
CC       step 2/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the transaldolase family. Type 2 subfamily.
XX
DR   Pfam; PF00923; TAL_FSA; 1; trigger=no
DR   PROSITE; PS00958; TRANSALDOLASE_2; 1; trigger=no
DR   PROSITE; PS01054; TRANSALDOLASE_1; 1; trigger=no
DR   NCBIfam; TIGR00876; tal_mycobact; 1; trigger=no
XX
KW   Cytoplasm
KW   Pentose shunt
KW   Schiff base
KW   Transferase
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GO   GO:0004801; F:transaldolase activity
GO   GO:0006098; P:pentose-phosphate shunt
GO   GO:0005737; C:cytoplasm
XX
FT   From: TAL_MYCTU (P9WG33)
FT   ACT_SITE        112
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   ACT_SITE        143
FT                   /note="Nucleophile; Schiff-base intermediate with
FT                   substrate"
FT   Condition: K
FT   BINDING         21
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: D
FT   BINDING         48
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: N
FT   BINDING         143
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: K
FT   BINDING         165
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: N
FT   BINDING         204
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: S
FT   BINDING         209
FT                   /ligand="D-fructose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:61527"
FT   Optional; Condition: R
XX
Size: 316-381;
Related: MF_00492; MF_00494; MF_00496;
Template: P48983; P0A870;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in STRCO
Plasmid: None
Comments: None
XX
# Version: 25
# Last updated date: 2025-11-26
# Created date: 2005-02-28
//