AC   MF_00495;
DC   Protein; auto
TR   HAMAP; MF_00495; -; 1; level=0
XX
Names: GPH_hydrolase_bact
XX
ID   GPH
DE   RecName: Full=Phosphoglycolate phosphatase;
DE            Short=PGP;
DE            Short=PGPase;
DE            EC=3.1.3.18;
case not <Property:PHOTOSYN>
GN   Name=gph;
end case
case <Property:PHOTOSYN>
GN   Name=cbbZ;
end case
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Specifically catalyzes the dephosphorylation of 2-
CC       phosphoglycolate. Is involved in the dissimilation of the intracellular
CC       2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate
CC       ends, a major class of DNA lesions induced by oxidative stress.
end case
case not <OC:Pseudomonadota>
CC   -!- FUNCTION: Specifically catalyzes the dephosphorylation of 2-
CC       phosphoglycolate.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phosphoglycolate + H2O = glycolate + phosphate;
CC         Xref=Rhea:RHEA:14369, ChEBI:CHEBI:15377, ChEBI:CHEBI:29805,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58033; EC=3.1.3.18;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Enterobacterales>
CC   -!- COFACTOR:
CC       Name=chloride; Xref=ChEBI:CHEBI:17996;
CC   -!- SUBUNIT: Monomer.
end case
CC   -!- PATHWAY: Organic acid metabolism; glycolate biosynthesis; glycolate
CC       from 2-phosphoglycolate: step 1/1.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       CbbY/CbbZ/Gph/YieH family.
XX
DR   Pfam; PF00702; Hydrolase; 1; trigger=no
DR   PRINTS; PR00413; HADHALOGNASE; 1; trigger=no
XX
KW   Carbohydrate metabolism
case <Property:PHOTOSYN>
KW   Calvin cycle
KW   Photosynthesis
end case
KW   Hydrolase
KW   Magnesium
KW   Metal-binding
case <OC:Enterobacterales>
KW   Chloride
end case
XX
GO   GO:0008967; F:phosphoglycolate phosphatase activity
GO   GO:0005975; P:carbohydrate metabolic process
case <Property:PHOTOSYN>
GO   GO:0019253; P:reductive pentose-phosphate cycle
end case
XX
FT   From: GPH_ECOLI (P32662)
FT   ACT_SITE        13
FT                   /note="Nucleophile"
FT   Condition: D
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         15
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         192
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
XX
Size: 212-272;
Related: None;
Template: P32662; P40852; P40853;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in CUPNH
Plasmid: in CUPNH
Comments: Possible overlap with other paralogous genes in many genomes.
 Divergent gph in SYNE7 not shown in alignment as it could well be a paralog.
XX
# Revision 1.39 2023/01/26
//