AC   MF_00504;
DC   Protein; auto
TR   HAMAP; MF_00504; -; 1; level=0
XX
Names: Aminopeptidase_M17
XX
ID   PEPB
DE   RecName: Full=Peptidase B;
DE            EC=3.4.11.23;
DE   AltName: Full=Aminopeptidase B;
GN   Name=pepB;
XX
CC   -!- FUNCTION: Probably plays an important role in intracellular peptide
CC       degradation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or
CC         arylamide. Xaa is preferably Glu or Asp but may be other amino acids,
CC         including Leu, Met, His, Cys and Gln.; EC=3.4.11.23;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit.;
CC   -!- SUBUNIT: Homohexamer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the peptidase M17 family.
XX
DR   Pfam; PF00883; Peptidase_M17; 1; trigger=no
DR   PRINTS; PR00481; LAMNOPPTDASE; 1; trigger=no
DR   PROSITE; PS00631; CYTOSOL_AP; 1; trigger=no
XX
KW   Cytoplasm
KW   Hydrolase
KW   Protease
KW   Aminopeptidase
KW   Manganese
KW   Metal-binding
XX
GO   GO:0004177; F:aminopeptidase activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0006508; P:proteolysis
GO   GO:0005737; C:cytoplasm
XX
FT   From: PEPB_ECOLI (P37095)
FT   ACT_SITE        207
FT   Condition: K
FT   ACT_SITE        281
FT   Condition: R
FT   BINDING         195
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: K
FT   BINDING         200
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         200
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         218
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         277
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         279
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         279
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: E
XX
Size: 427-456;
Related: MF_00181;
Template: P37095; Q9RF52;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.31 2022/11/19
//