AC   MF_00521;
DC   Protein; auto
TR   HAMAP; MF_00521; -; 1; level=0
XX
Names: KDO_kinase
XX
ID   KDKA
DE   RecName: Full=3-deoxy-D-manno-octulosonic acid kinase;
DE            Short=Kdo kinase;
DE            EC=2.7.1.166;
GN   Name=kdkA;
XX
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-
CC       manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH
CC       position.
case <OC:Escherichia>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-
CC         alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+);
CC         Xref=Rhea:RHEA:28506, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:60364, ChEBI:CHEBI:61589, ChEBI:CHEBI:456216;
CC         EC=2.7.1.166;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-
CC         (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:74271,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:176428,
CC         ChEBI:CHEBI:193140, ChEBI:CHEBI:456216; EC=2.7.1.166;
end case
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/RfaP
CC       family.
XX
DR   Pfam; PF06293; Kdo; 1; trigger=no
XX
KW   ATP-binding
KW   Cell inner membrane
KW   Cell membrane
KW   Kinase
KW   Lipopolysaccharide biosynthesis
KW   Membrane
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0016773; F:phosphotransferase activity, alcohol group as acceptor
GO   GO:0009103; P:lipopolysaccharide biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: KDKA_HAEIN (O86224)
FT   ACT_SITE        171
FT   Condition: D
XX
Size: 235-259;
Related: None;
Template: O86224;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.29 2022/09/25
//