AC   MF_00537;
DC   Protein; auto
c?   <OC:Bacteria> or <OG:Chloroplast>
TR   HAMAP; MF_00537; -; 1; level=0
XX
Names: Ribosomal_uS14_1
XX
case <OC:Bacteria> and not <OC:Cyanobacteriota>
ID   RS14
DE   RecName: Full=Small ribosomal subunit protein uS14;
GN   Name=rpsN;
else case <OC:Cyanobacteriota>
ID   RS14
DE   RecName: Full=Small ribosomal subunit protein uS14;
GN   Name=rpsN; Synonyms=rps14;
else case <OG:Chloroplast>
ID   RR14
DE   RecName: Full=Small ribosomal subunit protein uS14c;
GN   Name=rps14;
end case
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Binds 16S rRNA, required for the assembly of 30S particles
CC       and may also be responsible for determining the conformation of the 16S
CC       rRNA at the A site.
CC   -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts proteins S3 and
CC       S10.
end case
case <OG:Chloroplast>
CC   -!- FUNCTION: Binds 16S rRNA, required for the assembly of 30S particles.
CC   -!- SUBUNIT: Part of the 30S ribosomal subunit.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS14 family.
XX
DR   PROSITE; PS00527; RIBOSOMAL_S14; 1; trigger=no
DR   Pfam; PF00253; Ribosomal_S14; 1; trigger=no
XX
KW   Ribonucleoprotein
KW   Ribosomal protein
KW   RNA-binding
KW   rRNA-binding
XX
GO   GO:0006412; P:translation
GO   GO:0019843; F:rRNA binding
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
FT   None
XX
Size: 89-103;
Related: MF_01364;
Template: P0AG59; P0DOY6;
Scope:
 Bacteria
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in LIGS1
Comments: In bacteria this gene has been subject to horizontal gene transfer,
 subsequent differential gene loss and insertions/deletions near the N-terminus.
 The ancestral version is most likely the shortest one (group I of PubMed
 11102698) which has conserved cysteine residues that in the case of Thermus
 thermophilus have been shown to bind zinc. We have chosen to use the identifier
 RS14Z in bacteria for the zinc-binding subfamily (MF_01364). The group II
 proteins have an approximately 23 amino acid insertion and the group III
 proteins have an approximately 38 residue insertion; we do not distinguish
 between them however (this family, MF_00537); members of this subfamily do not
 usually possess the conserved cysteine residues. Many bacteria possess more
 than one copy of RS14, usually one of which is able to bind zinc.
 Interestingly, in the proteobacteria (Pseudomonadota, which usually have the
 group III form) the acquired form is found within the spc operon, signifying
 gene replacement took place within the operon.
 The proteins in Legionella species and SALRD match this family but have
 the conserved residues necessary to bind zinc; whether they do so is
 unknown.
 See:
 PubMed=11102698;
 Brochier C., Philippe H., Moreira D.;
 "The evolutionary history of ribosomal protein RpS14: horizontal gene
 transfer at the heart of the ribosome.";
 Trends Genet. 16:529-533(2000).
 PubMed=11574053;
 Makarova K.S., Ponomarev V.A., Koonin E.V.;
 "Two C or not two C: recurrent disruption of Zn-ribbons, gene
 duplication, lineage-specific gene loss, and horizontal gene transfer
 in evolution of bacterial ribosomal proteins.";
 Genome Biol. 2:RESEARCH 0033-RESEARCH 0033(2001).
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# Revision 1.19 2023/09/22
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