AC   MF_00540;
DC   Protein; auto
TR   HAMAP; MF_00540; -; 1; level=0
XX
Names: A_deaminase
XX
ID   ADD
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add;
XX
CC   -!- FUNCTION: Catalyzes the hydrolytic deamination of adenosine and 2-
CC       deoxyadenosine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine + H(+) + H2O = inosine + NH4(+);
CC         Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+);
CC         Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=3.5.4.4;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
XX
DR   Pfam; PF00962; A_deaminase; 1; trigger=no
DR   NCBIfam; TIGR01430; Aden_deam; 1; trigger=no
DR   PROSITE; PS00485; A_DEAMINASE; 1; trigger=no
XX
KW   Hydrolase
KW   Nucleotide metabolism
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0004000; F:adenosine deaminase activity
GO   GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: ADD_ECOLI (P22333)
FT   ACT_SITE        200
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         12
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         197
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         278
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: D
FT   BINDING         14
FT                   /ligand="substrate"
FT   Optional; Condition: H
FT   BINDING         16
FT                   /ligand="substrate"
FT   Optional; Condition: D
FT   BINDING         170
FT                   /ligand="substrate"
FT   Optional; Condition: G
FT   BINDING         279
FT                   /ligand="substrate"
FT   Optional; Condition: D
FT   SITE            221
FT                   /note="Important for catalytic activity"
FT   Condition: H
XX
Size: 299-396;
Related: None;
Template: P22333;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in STRCO
Plasmid: None
Comments: Possible wrong start in STRCO.
XX
# Revision 1.25 2023/06/01
//