AC   MF_00550;
DC   Protein; auto
TR   HAMAP; MF_00550; -; 1; level=0
XX
Names: Aminopeptidase_M20
XX
ID   PEPT
DE   RecName: Full=Peptidase T;
DE            EC=3.4.11.4;
DE   AltName: Full=Aminotripeptidase;
DE            Short=Tripeptidase;
DE   AltName: Full=Tripeptide aminopeptidase;
GN   Name=pepT;
XX
CC   -!- FUNCTION: Cleaves the N-terminal amino acid of tripeptides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of the N-terminal residue from a tripeptide.;
CC         EC=3.4.11.4;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 2 Zn(2+) ions per subunit.;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the peptidase M20B family.
XX
DR   PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1; trigger=no
DR   PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1; trigger=no
DR   Pfam; PF07687; M20_dimer; 1; trigger=no
DR   Pfam; PF01546; Peptidase_M20; 1; trigger=no
DR   NCBIfam; TIGR01882; Peptidase-T; 1; trigger=no
XX
KW   Cytoplasm
KW   Hydrolase
KW   Protease
KW   Aminopeptidase
KW   Metalloprotease
KW   Metal-binding
KW   Zinc
XX
GO   GO:0045148; F:tripeptide aminopeptidase activity
GO   GO:0008270; F:zinc ion binding
GO   GO:0006508; P:proteolysis
GO   GO:0043171; P:peptide catabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: PEPT_SALTY (P26311)
FT   ACT_SITE        80
FT   Condition: D
FT   ACT_SITE        173
FT                   /note="Proton acceptor"
FT   Condition: E
FT   BINDING         78
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         174
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: E
FT   BINDING         196
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         379
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: H
XX
Size: 406-413;
Related: None;
Template: P26311; P55179; P29745; P0C2T7; Q9L4G1; P81207; Q76HM7; Q76HM5; Q84BV2;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.35 2023/06/01
//