AC   MF_00564;
DC   Protein; auto
TR   HAMAP; MF_00564; -; 1; level=0
XX
Names: RNase_PH
XX
ID   RNPH
DE   RecName: Full=Ribonuclease PH;
DE            Short=RNase PH;
DE            EC=2.7.7.56;
DE   AltName: Full=tRNA nucleotidyltransferase;
GN   Name=rph;
XX
CC   -!- FUNCTION: Phosphorolytic 3'-5' exoribonuclease that plays an important
CC       role in tRNA 3'-end maturation. Removes nucleotide residues following
CC       the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of
CC       RNA molecules by using nucleoside diphosphates as substrates, but this
CC       may not be physiologically important. Probably plays a role in
CC       initiation of 16S rRNA degradation (leading to ribosome degradation)
CC       during starvation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate +
CC         tRNA(n); Xref=Rhea:RHEA:10628, Rhea:RHEA-COMP:17343, Rhea:RHEA-
CC         COMP:17344, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:173114;
CC         EC=2.7.7.56;
CC   -!- SUBUNIT: Homohexameric ring arranged as a trimer of dimers.
CC   -!- SIMILARITY: Belongs to the RNase PH family.
XX
DR   Pfam; PF01138; RNase_PH; 1; trigger=no
DR   Pfam; PF03725; RNase_PH_C; 1; trigger=no
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1; trigger=no
DR   NCBIfam; TIGR01966; RNasePH; 1; trigger=no
XX
KW   Transferase
KW   Nucleotidyltransferase
KW   rRNA processing
KW   tRNA processing
KW   tRNA-binding
XX
GO   GO:0000049; F:tRNA binding
GO   GO:0009022; F:tRNA nucleotidyltransferase activity
GO   GO:0008033; P:tRNA processing
GO   GO:0000175; F:3'-5'-RNA exonuclease activity
GO   GO:0016075; P:rRNA catabolic process
XX
FT   From: RNPH_PSEAE (P50597)
FT   BINDING         125..127
FT                   /ligand="phosphate"
FT                   /ligand_id="ChEBI:CHEBI:43474"
FT                   /ligand_note="substrate"
FT   Condition: [GS]-T-R
FT   BINDING         87
FT                   /ligand="phosphate"
FT                   /ligand_id="ChEBI:CHEBI:43474"
FT                   /ligand_note="substrate"
FT   Condition: R
XX
Size: 221-261;
Related: MF_00591; MF_00622;
Template: P28619; P0CG18; P0CG19;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.30 2023/07/27
//