AC   MF_00568;
DC   Protein; auto
TR   HAMAP; MF_00568; -; 1; level=0
XX
Names: NadA_type2
XX
ID   NADA
DE   RecName: Full=Quinolinate synthase;
DE            EC=2.5.1.72;
GN   Name=nadA;
XX
CC   -!- FUNCTION: Catalyzes the condensation of iminoaspartate with
CC       dihydroxyacetone phosphate to form quinolinate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O +
CC         phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster per subunit.;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from
CC       iminoaspartate: step 1/1.
case not <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the quinolinate synthase family. Type 2
CC       subfamily.
XX
DR   Pfam; PF02445; NadA; 1; trigger=no
DR   NCBIfam; TIGR00550; nadA; 1; trigger=no
XX
KW   4Fe-4S
case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   Pyridine nucleotide biosynthesis
KW   Transferase
XX
GO   GO:0008987; F:quinolinate synthetase A activity
GO   GO:0009435; P:NAD biosynthetic process
case not <OG:Chloroplast>
GO   GO:0005737; C:cytoplasm
end case
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
FT   From: NADA_PYRHO (O57767)
FT   BINDING         109..111
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: Y-[VIF]-N
FT   BINDING         196..198
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: H-P-E
FT   BINDING         83
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Condition: C
FT   BINDING         170
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Condition: C
FT   BINDING         256
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Condition: C
FT   BINDING         21
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: H
FT   BINDING         38
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: S
FT   BINDING         126
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: S
FT   BINDING         213
FT                   /ligand="iminosuccinate"
FT                   /ligand_id="ChEBI:CHEBI:77875"
FT   Condition: T
XX
Size: 298-377;
Related: MF_00567; MF_00569;
Template: O57767; Q9X1X7; Q8TZL3;
Scope:
 Bacteria
 Archaea
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in RHILO
Plasmid: in RHILO
Comments: None
XX
# Revision 1.39 2023/06/01
//