AC MF_00569; DC Protein; auto TR HAMAP; MF_00569; -; 1; level=0 XX Names: NadA_type3 XX ID NADA DE RecName: Full=Quinolinate synthase; DE EC=2.5.1.72; GN Name=nadA; XX CC -!- FUNCTION: Catalyzes the condensation of iminoaspartate with CC dihydroxyacetone phosphate to form quinolinate. CC -!- CATALYTIC ACTIVITY: CC Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + CC phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Note=Binds 1 [4Fe-4S] cluster per subunit.; CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from CC iminoaspartate: step 1/1. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the quinolinate synthase family. Type 3 CC subfamily. XX DR Pfam; PF02445; NadA; 1; trigger=no DR NCBIfam; TIGR00550; nadA; 1; trigger=no XX KW 4Fe-4S KW Cytoplasm KW Iron KW Iron-sulfur KW Metal-binding KW Pyridine nucleotide biosynthesis KW Transferase XX GO GO:0008987; F:quinolinate synthetase A activity GO GO:0009435; P:NAD biosynthetic process GO GO:0005737; C:cytoplasm XX FT From: NADA_BACSU (Q9KWZ1) FT BINDING 141..143 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: Y-x-N FT BINDING 256..258 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: H-P-E FT BINDING 110 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Condition: C FT BINDING 230 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Condition: C FT BINDING 320 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Condition: C FT BINDING 46 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: H FT BINDING 63 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: S FT BINDING 162 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: S FT BINDING 273 FT /ligand="iminosuccinate" FT /ligand_id="ChEBI:CHEBI:77875" FT Condition: T XX Size: 336-394; Related: MF_00567; MF_00568; Template: Q9KWZ1; O57767; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.36 2023/06/01 //