AC   MF_00570;
DC   Protein; auto
TR   HAMAP; MF_00570; -; 1; level=0
XX
Names: NAPRTase
XX
ID   PNCB
DE   RecName: Full=Nicotinate phosphoribosyltransferase;
DE            Short=NAPRTase;
DE            EC=6.3.4.21;
GN   Name=pncB;
XX
CC   -!- FUNCTION: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide
CC       from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of
CC       ATP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O +
CC         nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide +
CC         phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017,
CC         ChEBI:CHEBI:456216; EC=6.3.4.21;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC       ribonucleotide from nicotinate: step 1/1.
case <FTTag:phospho>
CC   -!- PTM: Transiently phosphorylated on a His residue during the reaction
CC       cycle. Phosphorylation strongly increases the affinity for substrates
CC       and increases the rate of nicotinate D-ribonucleotide production.
CC       Dephosphorylation regenerates the low-affinity form of the enzyme,
CC       leading to product release.
end case
CC   -!- SIMILARITY: Belongs to the NAPRTase family.
XX
DR   Pfam; PF04095; NAPRTase; 1; trigger=no
DR   PIRSF; PIRSF000484; NAPRT; 1; trigger=no
DR   NCBIfam; TIGR01514; NAPRTase; 1; trigger=no
XX
KW   Ligase
KW   Pyridine nucleotide biosynthesis
case <FTTag:phospho>
KW   Phosphoprotein
end case
XX
GO   GO:0004516; F:nicotinate phosphoribosyltransferase activity
GO   GO:0009435; P:NAD biosynthetic process
XX
FT   From: PNCB_SALTY (P22253)
FT   MOD_RES         220
FT                   /note="Phosphohistidine; by autocatalysis"
FT   Tag: phospho; Condition: H
XX
Size: 389-437;
Related: None;
Template: P18133; P22253;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSEAE
Plasmid: None
Comments: None
XX
# Revision 1.33 2023/06/01
//