AC   MF_00577;
DC   Protein; auto
TR   HAMAP; MF_00577; -; 1; level=0
XX
Names: HutU
XX
ID   HUTU
case <OC:Bacteria>
DE   RecName: Full=Urocanate hydratase;
DE            Short=Urocanase;
DE            EC=4.2.1.49;
DE   AltName: Full=Imidazolonepropionate hydrolase;
end case
case <OC:Archaea>
DE   RecName: Full=Probable urocanate hydratase;
DE            Short=Urocanase;
DE            EC=4.2.1.49;
DE   AltName: Full=Imidazolonepropionate hydrolase;
end case
GN   Name=hutU;
XX
CC   -!- FUNCTION: Catalyzes the conversion of urocanate to 4-imidazolone-5-
CC       propionate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-imidazolone-5-propanoate = H2O + trans-urocanate;
CC         Xref=Rhea:RHEA:13101, ChEBI:CHEBI:15377, ChEBI:CHEBI:17771,
CC         ChEBI:CHEBI:77893; EC=4.2.1.49;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC       Note=Binds 1 NAD(+) per subunit.;
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the urocanase family.
XX
DR   Pfam; PF01175; Urocanase; 1; trigger=no
DR   Pfam; PF17392; Urocanase_C; 1; trigger=no
DR   Pfam; PF17391; Urocanase_N; 1; trigger=no
DR   PIRSF; PIRSF001423; Urocanate_hydrat; 1; trigger=no
DR   NCBIfam; TIGR01228; hutU; 1; trigger=no
DR   PROSITE; PS01233; UROCANASE; 1; trigger=no
XX
KW   Cytoplasm
KW   Histidine metabolism
KW   Lyase
KW   NAD
XX
GO   GO:0016153; F:urocanate hydratase activity
GO   GO:0006548; P:histidine catabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: HUTU_BACSU (P25503)
FT   BINDING         49..50
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G-G
FT   BINDING         173..175
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G-M-G
FT   BINDING         239..240
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: N-A
FT   BINDING         260..264
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: Q-T-[SA]-A-H
FT   BINDING         270..271
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [YF]-[VIL]
FT   ACT_SITE        407
FT   Condition: C
FT   BINDING         127
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: Q
FT   BINDING         193
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [ED]
FT   BINDING         198
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: R
FT   BINDING         319
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: Y
FT   BINDING         489
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G
XX
Size: 520-680;
Related: None;
Template: P25080; P25503;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RHIME
Comments: None
XX
# Revision 1.28 2023/06/01
//