AC   MF_00578;
DC   Protein; auto
TR   HAMAP; MF_00578; -; 1; level=0
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Names: Glu_cys_ligase
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ID   GSH1
DE   RecName: Full=Glutamate--cysteine ligase;
DE            EC=6.3.2.2;
DE   AltName: Full=Gamma-ECS;
DE            Short=GCS;
DE   AltName: Full=Gamma-glutamylcysteine synthetase;
GN   Name=gshA;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine +
CC         ADP + phosphate + H(+); Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC   -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from
CC       L-cysteine and L-glutamate: step 1/2.
CC   -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 1 family.
CC       Type 1 subfamily.
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DR   Pfam; PF04262; Glu_cys_ligase; 1; trigger=no
DR   NCBIfam; TIGR01434; Glu_cys_ligase; 1; trigger=no
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KW   ATP-binding
KW   Glutathione biosynthesis
KW   Ligase
KW   Nucleotide-binding
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GO   GO:0004357; F:glutamate-cysteine ligase activity
GO   GO:0006750; P:glutathione biosynthetic process
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FT   None
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Size: 505-535;
Related: MF_00782;
Template: P0A6W9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Version: 17
# Last updated date: 2024-09-03
# Created date: 2005-02-28
//