AC   MF_00605;
DC   Protein; auto
TR   HAMAP; MF_00605; -; 1; level=0
XX
Names: TrmD
XX
ID   TRMD
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.228;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD;
XX
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.228;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase TrmD family.
XX
DR   Pfam; PF01746; tRNA_m1G_MT; 1; trigger=no
DR   NCBIfam; TIGR00088; TrmD; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   Transferase
KW   tRNA processing
KW   S-adenosyl-L-methionine
XX
GO   GO:0052906; F:tRNA (guanine(37)-N1)-methyltransferase activity
GO   GO:0006400; P:tRNA modification
GO   GO:0005737; C:cytoplasm
XX
FT   From: TRMD_ECOLI (P0A873)
FT   BINDING         133..138
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ILVM]-G-[DN]-[YF]-[IV]-[ILVM]
FT   BINDING         113
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
XX
Size: 222-361;
Related: None;
Template: P0A873;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: <Unknown>
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.30 2023/10/13
//