AC   MF_00607;
DC   Protein; auto
TR   HAMAP; MF_00607; -; 1; level=0
XX
Names: 16SrRNA_methyltr_A
XX
ID   RSMA
case <OC:Bacteria>
DE   RecName: Full=Ribosomal RNA small subunit methyltransferase A;
DE            EC=2.1.1.182;
DE   AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase;
DE   AltName: Full=16S rRNA dimethyladenosine transferase;
DE   AltName: Full=16S rRNA dimethylase;
DE   AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase;
else case <OC:Archaea>
DE   RecName: Full=Probable ribosomal RNA small subunit methyltransferase A;
DE            EC=2.1.1.-;
DE   AltName: Full=16S rRNA dimethyladenosine transferase;
DE   AltName: Full=16S rRNA dimethylase;
DE   AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase;
end case
GN   Name=rsmA; Synonyms=ksgA;
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Specifically dimethylates two adjacent adenosines (A1518 and
CC       A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA
CC       in the 30S particle. May play a critical role in biogenesis of 30S
CC       subunits.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-
CC         methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-
CC         dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:19609, Rhea:RHEA-COMP:10232, Rhea:RHEA-COMP:10233,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.182;
else case <OC:Archaea>
CC   -!- FUNCTION: Specifically dimethylates two adjacent adenosines in the loop
CC       of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.
CC       May play a critical role in biogenesis of 30S subunits.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. rRNA adenine N(6)-methyltransferase family. RsmA
CC       subfamily.
XX
DR   Pfam; PF00398; RrnaAD; 1; trigger=no
DR   NCBIfam; TIGR00755; KsgA; 1; trigger=no
DR   PROSITE; PS01131; RRNA_A_DIMETH; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   RNA-binding
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0016433; F:rRNA (adenine) methyltransferase activity
GO   GO:0000154; P:rRNA modification
GO   GO:0005737; C:cytoplasm
XX
FT   From: RSMA_ECOLI (P06992)
FT   BINDING         18
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [NH]
FT   BINDING         20
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ILVM]
FT   BINDING         45
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         66
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
FT   BINDING         91
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         113
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
XX
Size: 219-390;
Related: None;
Template: P06992; P13956;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.26 2023/06/01
//