AC MF_00635; DC Protein; auto TR HAMAP; MF_00635; -; 1; level=0 XX Names: dUTPase_arch XX ID DUT DE RecName: Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase; DE Short=dUTPase; DE EC=3.6.1.23; DE AltName: Full=dUTP pyrophosphatase; GN Name=dut; XX CC -!- FUNCTION: This enzyme is involved in nucleotide metabolism: it produces CC dUMP, the immediate precursor of thymidine nucleotides and it decreases CC the intracellular concentration of dUTP so that uracil cannot be CC incorporated into DNA. CC -!- CATALYTIC ACTIVITY: CC Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; CC -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP CC route): step 2/2. CC -!- SIMILARITY: Belongs to the dCTP deaminase family. Archaeal dUTPase CC subfamily. XX DR Pfam; PF00692; dUTPase; 1; trigger=no XX KW Hydrolase KW Nucleotide metabolism XX GO GO:0004170; F:dUTP diphosphatase activity GO GO:0006226; P:dUMP biosynthetic process XX FT None XX Size: 150-171; Related: MF_00146; Template: Q58502; Scope: Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.15 2024/01/25 //