AC   MF_00636;
DC   Protein; auto
TR   HAMAP; MF_00636; -; 1; level=0
XX
Names: RapZ_like
XX
case <OC:Enterobacterales>
ID   RAPZ
DE   RecName: Full=RNase adapter protein RapZ;
GN   Name=rapZ;
else
ID   Ynnn
DE   RecName: Full=Nucleotide-binding protein <locus_tag>;
end case
XX
case <OC:Enterobacterales>
CC   -!- FUNCTION: Modulates the synthesis of GlmS, by affecting the processing
CC       and stability of the regulatory small RNA GlmZ. When glucosamine-6-
CC       phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ
CC       and targets it to cleavage by RNase E. Consequently, GlmZ is
CC       inactivated and unable to activate GlmS synthesis. Under low GlcN6P
CC       concentrations, RapZ is sequestered and inactivated by an other
CC       regulatory small RNA, GlmY, preventing GlmZ degradation and leading to
CC       synthesis of GlmS.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SIMILARITY: Belongs to the RapZ-like family. RapZ subfamily.
else
CC   -!- FUNCTION: Displays ATPase and GTPase activities.
CC   -!- SIMILARITY: Belongs to the RapZ-like family.
end case
XX
DR   Pfam; PF03668; ATP_bind_2; 1; trigger=no
DR   PIRSF; PIRSF005052; P-loopkin; 1; trigger=no
XX
case <OC:Enterobacterales>
KW   RNA-binding
end case
KW   ATP-binding
KW   GTP-binding
KW   Nucleotide-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0005525; F:GTP binding
XX
FT   From: RAPZ_ECOLI (P0A894)
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x(2)-G-[SAG]-G-[KR]-x
FT   BINDING         56..59
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Condition: D-x-R-x
case <OC:Enterobacterales>
FT   REGION          266..Cter
FT                   /note="RNA-binding"
end case
XX
Size: 261-372;
Related: None;
Template: O06973; P0A894;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Homologs of RapZ are present in a wide range of bacteria indicating an important function.
 However, in bacteria that do not possess sRNAs GlmY and GlmZ, the role of RapZ homologs remains elusive.
 (see PubMed:24667238)
XX
# Revision 1.35 2022/11/19
//