AC   MF_00637;
DC   Protein; auto
TR   HAMAP; MF_00637; -; 1; level=0
XX
Names: Anti_sigma_F
XX
ID   SP2AB
DE   RecName: Full=Anti-sigma F factor;
DE            EC=2.7.11.1;
DE   AltName: Full=Stage II sporulation protein AB;
GN   Name=spoIIAB;
XX
CC   -!- FUNCTION: Binds to sigma F and blocks its ability to form an RNA
CC       polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine
CC       residue. This phosphorylation may enable SpoIIAA to act as an anti-
CC       anti-sigma factor that counteracts SpoIIAB and thus releases sigma F
CC       from inhibition.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor family.
XX
DR   Pfam; PF02518; HATPase_c; 1; trigger=no
DR   NCBIfam; TIGR01925; spIIAB; 1; trigger=no
XX
KW   ATP-binding
KW   Kinase
KW   Nucleotide-binding
KW   Sporulation
KW   Serine/threonine-protein kinase
KW   Transferase
XX
GO   GO:0004672; F:protein kinase activity
GO   GO:0010468; P:regulation of gene expression
GO   GO:0030436; P:asexual sporulation
XX
FT   None
XX
Size: 140-151;
Related: MF_00638;
Template: P10728;
Scope:
 Bacteria; Bacillales
 Bacteria; Clostridia
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.20 2023/06/01
//