AC   MF_00648;
DC   Protein; auto
TR   HAMAP; MF_00648; -; 1; level=0
XX
Names: Non_canon_purine_NTPase_YjjX
XX
ID   NCPP
case <OC:Pseudomonadota>
DE   RecName: Full=Inosine/xanthosine triphosphatase;
DE            Short=ITPase/XTPase;
DE            EC=3.6.1.73;
DE   AltName: Full=Non-canonical purine NTP phosphatase;
DE   AltName: Full=Non-standard purine NTP phosphatase;
DE   AltName: Full=Nucleoside-triphosphate phosphatase;
DE            Short=NTPase;
else
DE   RecName: Full=Probable inosine/xanthosine triphosphatase;
DE            Short=ITPase/XTPase;
DE            EC=3.6.1.73;
DE   AltName: Full=Non-canonical purine NTP phosphatase;
DE   AltName: Full=Non-standard purine NTP phosphatase;
DE   AltName: Full=Nucleoside-triphosphate phosphatase;
DE            Short=NTPase;
end case
XX
CC   -!- FUNCTION: Phosphatase that hydrolyzes non-canonical purine nucleotides
CC       such as XTP and ITP to their respective diphosphate derivatives.
CC       Probably excludes non-canonical purines from DNA/RNA precursor pool,
CC       thus preventing their incorporation into DNA/RNA and avoiding
CC       chromosomal lesions.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + XTP = H(+) + phosphate + XDP; Xref=Rhea:RHEA:28406,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:59884, ChEBI:CHEBI:61314; EC=3.6.1.73;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; EC=3.6.1.73;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 1 divalent metal cation per subunit; can use either Mg(2+)
CC       or Mn(2+).;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the YjjX NTPase family.
XX
DR   Pfam; PF01931; NTPase_I-T; 1; trigger=no
DR   NCBIfam; TIGR00258; TIGR00258; 1; trigger=no
XX
KW   Hydrolase
KW   Magnesium
KW   Manganese
KW   Metal-binding
KW   Nucleotide metabolism
KW   Nucleotide-binding
XX
GO   GO:0017111; F:ribonucleoside triphosphate phosphatase activity
XX
FT   From: NCPP_ECOLI (P39411)
FT   BINDING         8..13
FT                   /ligand="substrate"
FT   Condition: [TS]-[TS]-x-x-x-[K]
FT   BINDING         68..69
FT                   /ligand="substrate"
FT   Condition: [ED]-[AGV]
FT   BINDING         38
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [ED]
FT   BINDING         68
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [EQD]
XX
Size: 169-197;
Related: None;
Template: P39411;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_00647 (coaD)
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.38 2023/06/01
//