AC   MF_00649;
DC   Protein; auto
TR   HAMAP; MF_00649; -; 1; level=0
XX
Names: DNA_gyrase_inhibitor_YacG
XX
ID   YACG
DE   RecName: Full=DNA gyrase inhibitor YacG;
GN   Name=yacG;
XX
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to the C-
CC       terminal domain of GyrB, which probably disrupts DNA binding by the
CC       gyrase.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion.;
end case
CC   -!- SUBUNIT: Interacts with GyrB.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
XX
DR   Pfam; PF03884; DUF329; 1; trigger=no
XX
case <FTGroup:1>
KW   Zinc
KW   Metal-binding
end case
XX
GO   GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: YACG_ECOLI (P0A8H8)
FT   BINDING         9
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         12
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         28
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 48-82;
Related: None;
Template: P0A8H8;
Scope:
 Bacteria; Pseudomonadota
 Bacteria; Planctomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.28 2023/01/26
//