AC   MF_00658;
DC   Protein; auto
TR   HAMAP; MF_00658; -; 1; level=0
XX
Names: 23SrRNA_methyltr_H
XX
ID   RLMH
case <OC:Bacteria>
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase H;
DE            EC=2.1.1.177;
DE   AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
DE   AltName: Full=23S rRNA m3Psi1915 methyltransferase;
DE   AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
else case <OC:Archaea>
DE   RecName: Full=Putative ribosomal RNA large subunit methyltransferase H;
DE            EC=2.1.1.177;
DE   AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
DE   AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
end case
GN   Name=rlmH;
XX
CC   -!- FUNCTION: Specifically methylates the pseudouridine at position 1915
CC       (m3Psi1915) in 23S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine =
CC         H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:42752, Rhea:RHEA-COMP:10221, Rhea:RHEA-
CC         COMP:10222, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:74486; EC=2.1.1.177;
case <OC:Bacteria>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase RlmH family.
XX
DR   Pfam; PF02590; SPOUT_MTase; 1; trigger=no
DR   PIRSF; PIRSF004505; MT_bac; 1; trigger=no
DR   NCBIfam; TIGR00246; tRNA_RlmH_YbeA; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0070038; F:rRNA (pseudouridine-N3-)-methyltransferase activity
GO   GO:0031167; P:rRNA methylation
GO   GO:0005737; C:cytoplasm
XX
FT   From: RLMH_ECOLI (P0A8I8)
FT   BINDING         122..127
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [LIVFM]-[GAST]-x-[LIM]-x-[LMFYW]
FT   BINDING         72
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [LI]
FT   BINDING         103
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [GA]
XX
Size: 120-210;
Related: None;
Template: P0A8I8; P0C1V0;
Scope:
 Bacteria
 Archaea; Euryarchaeota
Fusion:
 Nter: None
 Cter: None
Duplicate: in CLOPS, ECODH, THEP3, THEPX, CALS4
Plasmid: None
Comments: None
XX
# Revision 1.35 2023/06/01
//