AC   MF_00660;
DC   Protein; auto
TR   HAMAP; MF_00660; -; 1; level=0
XX
Names: PqqE
XX
ID   PQQE
DE   RecName: Full=PqqA peptide cyclase;
DE            EC=1.21.98.4;
DE   AltName: Full=Coenzyme PQQ synthesis protein E;
GN   Name=pqqE;
XX
CC   -!- FUNCTION: Catalyzes the cross-linking of a glutamate residue and a
CC       tyrosine residue in the PqqA protein as part of the biosynthesis of
CC       pyrroloquinoline quinone (PQQ).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-
CC         deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:56836, Rhea:RHEA-COMP:14800, Rhea:RHEA-
CC         COMP:14801, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:141026, ChEBI:CHEBI:141027;
CC         EC=1.21.98.4;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
CC   -!- SUBUNIT: Interacts with PqqD. The interaction is necessary for activity
CC       of PqqE.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. PqqE family.
XX
DR   Pfam; PF04055; Radical_SAM; 1; trigger=no
DR   PIRSF; PIRSF037420; PQQ_syn_pqqE; 1; trigger=no
DR   NCBIfam; TIGR02109; PQQ_syn_pqqE; 1; trigger=no
DR   PROSITE; PS01305; MOAA_NIFB_PQQE; 1; trigger=no
DR   PROSITE; PS51918; RADICAL_SAM; 1; trigger=yes
XX
KW   Oxidoreductase
KW   PQQ biosynthesis
case <FTGroup:1>
KW   4Fe-4S
KW   Metal-binding
KW   Iron
KW   Iron-sulfur
KW   S-adenosyl-L-methionine
end case
XX
GO   GO:0009975; F:cyclase activity
GO   GO:1904047; F:S-adenosyl-L-methionine binding
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0018189; P:pyrroloquinoline quinone biosynthetic process
XX
FT   From: PQQE_ACICA (P07782)
FT   BINDING         19
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         23
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         26
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
XX
Size: 358-399;
Related: None;
Template: P71517; P27507;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RHIME, STRRO
Comments: None
XX
# Revision 1.34 2023/06/01
//