AC   MF_00688;
DC   Protein; auto
TR   HAMAP; MF_00688; -; 1; level=0
XX
Names: Leu_Phe_trans
XX
ID   LFTR
DE   RecName: Full=Leucyl/phenylalanyl-tRNA--protein transferase;
DE            EC=2.3.2.6;
DE   AltName: Full=L/F-transferase;
DE   AltName: Full=Leucyltransferase;
DE   AltName: Full=Phenyalanyltransferase;
GN   Name=aat;
XX
CC   -!- FUNCTION: Functions in the N-end rule pathway of protein degradation
CC       where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-
CC       tRNAs to the N-termini of proteins containing an N-terminal arginine or
CC       lysine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-
CC         terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu);
CC         Xref=Rhea:RHEA:12340, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622,
CC         Rhea:RHEA-COMP:12670, Rhea:RHEA-COMP:12671, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:65249, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494,
CC         ChEBI:CHEBI:133043; EC=2.3.2.6;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) +
CC         N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu);
CC         Xref=Rhea:RHEA:50416, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622,
CC         Rhea:RHEA-COMP:12672, Rhea:RHEA-COMP:12673, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:64719, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494,
CC         ChEBI:CHEBI:133044; EC=2.3.2.6;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-
CC         tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein]
CC         + tRNA(Phe); Xref=Rhea:RHEA:43632, Rhea:RHEA-COMP:9668, Rhea:RHEA-
CC         COMP:9699, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10637,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:78597,
CC         ChEBI:CHEBI:83561; EC=2.3.2.6;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the L/F-transferase family.
XX
DR   Pfam; PF03588; Leu_Phe_trans; 1; trigger=no
DR   NCBIfam; TIGR00667; Aat; 1; trigger=no
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KW   Cytoplasm
KW   Transferase
KW   Acyltransferase
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GO   GO:0008914; F:leucyl-tRNA--protein transferase activity
GO   GO:0030163; P:protein catabolic process
GO   GO:0005737; C:cytoplasm
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FT   None
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Size: 191-274;
Related: None;
Template: P0A8P1;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in RHOPB
Plasmid: None
Comments: None
XX
# Revision 1.25 2023/07/28
//