AC   MF_00700;
DC   Protein; auto
TR   HAMAP; MF_00700; -; 1; level=0
XX
Names: DNA_primase_sml_arc
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ID   PRIS
DE   RecName: Full=DNA primase small subunit PriS;
DE            EC=2.7.7.-;
GN   Name=priS;
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CC   -!- FUNCTION: Catalytic subunit of DNA primase, an RNA polymerase that
CC       catalyzes the synthesis of short RNA molecules used as primers for DNA
CC       polymerase during DNA replication. The small subunit contains the
CC       primase catalytic core and has DNA synthesis activity on its own.
CC       Binding to the large subunit stabilizes and modulates the activity,
CC       increasing the rate of DNA synthesis while decreasing the length of the
CC       DNA fragments, and conferring RNA synthesis capability. The DNA
CC       polymerase activity may enable DNA primase to also catalyze primer
CC       extension after primer synthesis. May also play a role in DNA repair.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- SUBUNIT: Heterodimer of a small subunit (PriS) and a large subunit
CC       (PriL).
CC   -!- SIMILARITY: Belongs to the eukaryotic-type primase small subunit
CC       family.
XX
DR   Pfam; PF01896; DNA_primase_S; 1; trigger=no
DR   NCBIfam; TIGR00335; Primase_sml; 1; trigger=no
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KW   DNA replication
KW   DNA-directed RNA polymerase
KW   Magnesium
KW   Manganese
KW   Metal-binding
KW   Nucleotidyltransferase
KW   Primosome
KW   Transcription
KW   Transferase
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GO   GO:0003896; F:DNA primase activity
GO   GO:0006269; P:DNA replication, synthesis of RNA primer
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FT   From: PRIS_PYRHO (O57934)
FT   ACT_SITE        95
FT   Condition: D
FT   ACT_SITE        97
FT   Condition: D
FT   ACT_SITE        280
FT   Condition: D
XX
Size: 296-442;
Related: None;
Template: O57934; Q9P9H1; Q97Z83; Q5JJ72; Q58249; Q9V292;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.20 2023/06/01
//