AC MF_00701; DC Protein; auto TR HAMAP; MF_00701; -; 1; level=0 XX Names: DNA_primase_lrg_arc XX ID PRIL DE RecName: Full=DNA primase large subunit PriL; GN Name=priL; XX CC -!- FUNCTION: Regulatory subunit of DNA primase, an RNA polymerase that CC catalyzes the synthesis of short RNA molecules used as primers for DNA CC polymerase during DNA replication. Stabilizes and modulates the CC activity of the small subunit, increasing the rate of DNA synthesis, CC and conferring RNA synthesis capability. The DNA polymerase activity CC may enable DNA primase to also catalyze primer extension after primer CC synthesis. May also play a role in DNA repair. case CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Note=Binds 1 [4Fe-4S] cluster.; end case CC -!- SUBUNIT: Heterodimer of a small subunit (PriS) and a large subunit CC (PriL). CC -!- SIMILARITY: Belongs to the eukaryotic-type primase large subunit CC family. XX DR Pfam; PF04104; DNA_primase_lrg; 1; trigger=no XX KW DNA replication KW Primosome case KW 4Fe-4S KW Iron KW Iron-sulfur KW Metal-binding end case XX case GO GO:0051539; F:4 iron, 4 sulfur cluster binding end case GO GO:0006269; P:DNA replication, synthesis of RNA primer XX FT From: PRIL_SACS2 (Q9UWW1) FT BINDING 216 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Optional; Group: 1; Condition: C FT BINDING 280 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Optional; Group: 1; Condition: C FT BINDING 289 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Optional; Group: 1; Condition: C FT BINDING 293 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT Optional; Group: 1; Condition: C XX Size: 295-500; Related: None; Template: Q9UWW1; Q8U4H7; O57935; Q5JJ73; Q9V291; Scope: Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.21 2022/11/19 //