AC   MF_00719;
DC   Protein; auto
TR   HAMAP; MF_00719; -; 1; level=0
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Names: CobS
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ID   COBS
DE   RecName: Full=Adenosylcobinamide-GDP ribazoletransferase;
DE            EC=2.7.8.26;
DE   AltName: Full=Cobalamin-5'-phosphate synthase;
DE   AltName: Full=Cobalamin synthase;
GN   Name=cobS;
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CC   -!- FUNCTION: Joins adenosylcobinamide-GDP and alpha-ribazole to generate
CC       adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin
CC       5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-
CC       phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosylcob(III)inamide-GDP + alpha-ribazole =
CC         adenosylcob(III)alamin + GMP + H(+); Xref=Rhea:RHEA:16049,
CC         ChEBI:CHEBI:10329, ChEBI:CHEBI:15378, ChEBI:CHEBI:18408,
CC         ChEBI:CHEBI:58115, ChEBI:CHEBI:60487; EC=2.7.8.26;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate =
CC         adenosylcob(III)alamin 5'-phosphate + GMP + H(+);
CC         Xref=Rhea:RHEA:23560, ChEBI:CHEBI:15378, ChEBI:CHEBI:57918,
CC         ChEBI:CHEBI:58115, ChEBI:CHEBI:60487, ChEBI:CHEBI:60493; EC=2.7.8.26;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the CobS family.
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DR   Pfam; PF02654; CobS; 1; trigger=no
DR   PRINTS; PR01036; TCRTETB; 1; trigger=no
DR   NCBIfam; TIGR00317; CobS; 1; trigger=no
DR   General; Transmembrane; -; 4-8; trigger=yes
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case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Cobalamin biosynthesis
KW   Magnesium
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0008818; F:cobalamin 5'-phosphate synthase activity
GO   GO:0051073; F:adenosylcobinamide-GDP ribazoletransferase activity
GO   GO:0009236; P:cobalamin biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   None
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Size: 199-307;
Related: None;
Template: P36561; P29936; Q05602;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARCFU
Plasmid: None
Comments: None
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# Revision 1.37 2023/06/01
//