AC   MF_00733;
DC   Protein; auto
TR   HAMAP; MF_00733; -; 1; level=0
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Names: RocA
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ID   ROCA
DE   RecName: Full=1-pyrroline-5-carboxylate dehydrogenase;
DE            Short=P5C dehydrogenase;
DE            EC=1.2.1.88;
DE   AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase;
GN   Name=rocA;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC         glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. RocA
CC       subfamily.
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DR   Pfam; PF00171; Aldedh; 1; trigger=no
DR   NCBIfam; TIGR01237; D1pyr5carbox2; 1; trigger=no
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1; trigger=no
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1; trigger=no
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KW   Oxidoreductase
KW   NAD
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GO   GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity
GO   GO:0006537; P:glutamate biosynthetic process
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FT   From: ROCA_BACSU (P39634)
FT   ACT_SITE        286
FT   Condition: E
FT   ACT_SITE        320
FT   Condition: C
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Size: 514-515;
Related: None;
Template: P39634;
Scope:
 Bacteria; Bacillales
Fusion:
 Nter: None
 Cter: None
Duplicate: in HALH5, BACSU
Plasmid: None
Comments: None
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# Revision 1.22 2023/06/01
//