AC   MF_00737;
DC   Protein; auto
TR   HAMAP; MF_00737; -; 1; level=0
XX
Names: Formimidoylglutam
XX
case <OS:Pseudomonas>
ID   HUTGL
else
ID   HUTG
end case
DE   RecName: Full=Formimidoylglutamase;
DE            EC=3.5.3.8;
DE   AltName: Full=Formiminoglutamase;
DE   AltName: Full=Formiminoglutamate hydrolase;
case not <OS:Pseudomonas>
GN   Name=hutG;
end case
XX
CC   -!- FUNCTION: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-
CC       glutamate and formamide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate;
CC         Xref=Rhea:RHEA:22492, ChEBI:CHEBI:15377, ChEBI:CHEBI:16397,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58928; EC=3.5.3.8;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit.;
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the arginase family.
XX
DR   Pfam; PF00491; Arginase; 1; trigger=no
DR   PIRSF; PIRSF036979; Arginase; 1; trigger=no
DR   PRINTS; PR00116; ARGINASE; 1; trigger=no
DR   NCBIfam; TIGR01227; hutG; 1; trigger=no
DR   PROSITE; PS01053; ARGINASE_1; 1; trigger=no
DR   PROSITE; PS51409; ARGINASE_2; 1; trigger=no
XX
KW   Hydrolase
KW   Histidine metabolism
case <FTGroup:1>
KW   Metal-binding
KW   Manganese
end case
XX
GO   GO:0050415; F:formimidoylglutamase activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0006548; P:histidine catabolic process
XX
FT   From: HUTG_BACSU (P42068)
FT   BINDING         127
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: [HN]
FT   BINDING         150
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         150
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
FT   BINDING         152
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: H
FT   BINDING         154
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         242
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: [DC]
FT   BINDING         242
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: [DC]
FT   BINDING         244
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
XX
Size: 306-364;
Related: None;
Template: P42068;
Scope:
 Bacteria
 Archaea; Halobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.25 2023/06/01
//