AC   MF_00747;
DC   Protein; auto
TR   HAMAP; MF_00747; -; 1; level=0
XX
Names: AceK
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ID   ACEK
DE   RecName: Full=Isocitrate dehydrogenase kinase/phosphatase;
DE            Short=IDH kinase/phosphatase;
DE            Short=IDHK/P;
DE            EC=2.7.11.5;
DE            EC=3.1.3.-;
GN   Name=aceK;
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CC   -!- FUNCTION: Bifunctional enzyme which can phosphorylate or
CC       dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine
CC       residue. This is a regulatory mechanism which enables bacteria to
CC       bypass the Krebs cycle via the glyoxylate shunt in response to the
CC       source of carbon. When bacteria are grown on glucose, IDH is fully
CC       active and unphosphorylated, but when grown on acetate or ethanol, the
CC       activity of IDH declines drastically concomitant with its
CC       phosphorylation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-
CC         phospho-L-seryl-[isocitrate dehydrogenase]; Xref=Rhea:RHEA:43540,
CC         Rhea:RHEA-COMP:10605, Rhea:RHEA-COMP:10606, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.5;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the AceK family.
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DR   Pfam; PF06315; AceK; 1; trigger=no
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KW   Cytoplasm
KW   ATP-binding
KW   Glyoxylate bypass
KW   Hydrolase
KW   Kinase
KW   Nucleotide-binding
KW   Protein phosphatase
KW   Serine/threonine-protein kinase
KW   Transferase
KW   Tricarboxylic acid cycle
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GO   GO:0005524; F:ATP binding
GO   GO:0016788; F:hydrolase activity, acting on ester bonds
GO   GO:0008772; F:[isocitrate dehydrogenase (NADP+)] kinase activity
GO   GO:0006097; P:glyoxylate cycle
GO   GO:0006099; P:tricarboxylic acid cycle
GO   GO:0005737; C:cytoplasm
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FT   From: ACEK_ECOLI (P11071)
FT   BINDING         315..321
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: A-x-G-x-x-G-[LIVMT]
FT   ACT_SITE        371
FT   Condition: D
FT   BINDING         336
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: K
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Size: 564-625;
Related: None;
Template: P11071;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSET1
Plasmid: None
Comments: None
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# Revision 1.34 2023/01/26
//