AC   MF_00750;
DC   Protein; auto
TR   HAMAP; MF_00750; -; 1; level=0
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Names: Choline_dehydrogen
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ID   BETA
DE   RecName: Full=Oxygen-dependent choline dehydrogenase;
DE            Short=CDH;
DE            Short=CHD;
DE            EC=1.1.99.1;
DE   AltName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betA;
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CC   -!- FUNCTION: Involved in the biosynthesis of the osmoprotectant glycine
CC       betaine. Catalyzes the oxidation of choline to betaine aldehyde and
CC       betaine aldehyde to glycine betaine at the same rate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710,
CC         ChEBI:CHEBI:17499; EC=1.1.99.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15710, ChEBI:CHEBI:17750, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.8;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC       choline pathway; betaine aldehyde from choline (cytochrome c reductase
CC       route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   Pfam; PF05199; GMC_oxred_C; 1; trigger=no
DR   Pfam; PF00732; GMC_oxred_N; 1; trigger=no
DR   NCBIfam; TIGR01810; BetA; 1; trigger=no
DR   PROSITE; PS00623; GMC_OXRED_1; 1; trigger=no
DR   PROSITE; PS00624; GMC_OXRED_2; 1; trigger=no
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KW   Oxidoreductase
KW   Flavoprotein
KW   FAD
KW   NAD
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GO   GO:0008812; F:choline dehydrogenase activity
GO   GO:0019285; P:glycine betaine biosynthetic process from choline
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FT   From: BETA_ECOLI (P17444)
FT   BINDING         4..33
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   ACT_SITE        473
FT                   /note="Proton acceptor"
FT   Condition: H
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Size: 549-572;
Related: None;
Template: P17444;
Scope:
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.31 2023/06/01
//