AC   MF_00757;
DC   Protein; auto
TR   HAMAP; MF_00757; -; 1; level=0
XX
Names: RNase_P_4
XX
ID   RNP4
DE   RecName: Full=Ribonuclease P protein component 4;
DE            Short=RNase P component 4;
DE            EC=3.1.26.5;
DE   AltName: Full=Rpp21;
GN   Name=rnp4;
XX
CC   -!- FUNCTION: Part of ribonuclease P, a protein complex that generates
CC       mature tRNA molecules by cleaving their 5'-ends.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBUNIT: Consists of a catalytic RNA component and at least 4-5 protein
CC       subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein
CC       component 4 family.
XX
DR   Pfam; PF04032; Rpr2; 1; trigger=no
XX
KW   Cytoplasm
KW   Endonuclease
KW   Hydrolase
KW   Nuclease
KW   tRNA processing
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0004526; F:ribonuclease P activity
GO   GO:0001682; P:tRNA 5'-leader removal
GO   GO:0030677; C:ribonuclease P complex
GO   GO:0005737; C:cytoplasm
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: RNP4_PYRHO (O59248)
FT   BINDING         68
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 91-140;
Related: None;
Template: O27655; O59248; P62378; Q58372; Q8U0H6;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Zinc-binding residues are conserved in eukaryotes too, even
 though they aren't members of this family.
XX
# Revision 1.16 2022/11/19
//