AC   MF_00782;
DC   Protein; auto
TR   HAMAP; MF_00782; -; 1; level=0
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Names: Glut_biosynth
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ID   GSHAB
DE   RecName: Full=Glutathione biosynthesis bifunctional protein GshAB;
DE   AltName: Full=Gamma-GCS-GS;
DE            Short=GCS-GS;
DE   Includes:
DE     RecName: Full=Glutamate--cysteine ligase;
DE              EC=6.3.2.2;
DE     AltName: Full=Gamma-ECS;
DE              Short=GCS;
DE     AltName: Full=Gamma-glutamylcysteine synthetase;
DE   Includes:
DE     RecName: Full=Glutathione synthetase;
DE              EC=6.3.2.3;
DE     AltName: Full=GSH synthetase;
DE              Short=GS;
DE              Short=GSH-S;
DE              Short=GSHase;
DE     AltName: Full=Glutathione synthase;
GN   Name=gshAB; Synonyms=gshF;
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CC   -!- FUNCTION: Synthesizes glutathione from L-glutamate and L-cysteine via
CC       gamma-L-glutamyl-L-cysteine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC         cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP +
CC         glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173,
CC         ChEBI:CHEBI:456216; EC=6.3.2.3;
CC   -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from
CC       L-cysteine and L-glutamate: step 1/2.
CC   -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from
CC       L-cysteine and L-glutamate: step 2/2.
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the glutamate--
CC       cysteine ligase type 1 family. Type 2 subfamily.
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DR   Pfam; PF04262; Glu_cys_ligase; 1; trigger=no
DR   NCBIfam; TIGR01435; Glu_cys_lig_rel; 1; trigger=no
DR   PROSITE; PS50975; ATP_GRASP; 1; trigger=yes
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KW   ATP-binding
KW   Glutathione biosynthesis
KW   Ligase
KW   Multifunctional enzyme
KW   Nucleotide-binding
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GO   GO:0005524; F:ATP binding
GO   GO:0004363; F:glutathione synthase activity
GO   GO:0004357; F:glutamate-cysteine ligase activity
GO   GO:0006750; P:glutathione biosynthetic process
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FT   From: GSHAB_STRA5 (Q8DXM9)
FT   REGION          Nter..333
FT                   /note="Glutamate--cysteine ligase"
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Size: 750-779;
Related: MF_00578;
Template: Q8DXM9;
Scope:
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.26 2023/06/01
//