AC MF_00801; DC Protein; auto TR HAMAP; MF_00801; -; 1; level=0 XX Names: Endonuclease_5 XX ID NFI DE RecName: Full=Endonuclease V; DE EC=3.1.21.7; DE AltName: Full=Deoxyinosine 3'endonuclease; DE AltName: Full=Deoxyribonuclease V; DE Short=DNase V; GN Name=nfi; XX CC -!- FUNCTION: DNA repair enzyme involved in the repair of deaminated bases. CC Selectively cleaves double-stranded DNA at the second phosphodiester CC bond 3' to a deoxyinosine leaving behind the intact lesion on the CC nicked DNA. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to CC products with a 5'-phosphate.; EC=3.1.21.7; case CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; end case CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the endonuclease V family. XX DR Pfam; PF04493; Endonuclease_5; 1; trigger=no XX KW Cytoplasm KW DNA damage KW DNA repair KW Endonuclease KW Hydrolase case KW Magnesium KW Metal-binding end case KW Nuclease XX case GO GO:0000287; F:magnesium ion binding end case GO GO:0043737; F:deoxyribonuclease V activity GO GO:0006281; P:DNA repair GO GO:0005737; C:cytoplasm XX FT From: NFI_THEMA (Q9X2H9) FT BINDING 43 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Group: 1; Condition: D FT BINDING 110 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Group: 1; Condition: [DEN] FT SITE 80 FT /note="Interaction with target DNA" FT Condition: Y XX Size: 191-290; Related: None; Template: P68739; O30108; Q9X2H9; Scope: Bacteria Archaea Fusion: Nter: Cter: None Duplicate: None Plasmid: None Comments: Some archaea are bifunctional and contain a N-terminal methyltransferase domain. XX # Revision 1.29 2022/11/19 //