AC   MF_00811;
DC   Protein; auto
TR   HAMAP; MF_00811; -; 1; level=0
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Names: DapD
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ID   DAPD
DE   RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
DE            EC=2.3.1.117;
DE   AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
DE            Short=THDP succinyltransferase;
DE            Short=THP succinyltransferase;
DE            Short=Tetrahydropicolinate succinylase;
GN   Name=dapD;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-
CC         2-succinylamino-6-oxoheptanedioate + CoA; Xref=Rhea:RHEA:17325,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15685, ChEBI:CHEBI:16845,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=2.3.1.117;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate
CC       (succinylase route): step 1/3.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
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DR   Pfam; PF00132; Hexapep; 5; trigger=no
DR   NCBIfam; TIGR00965; DapD; 1; trigger=no
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1; trigger=no
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KW   Acyltransferase
KW   Amino-acid biosynthesis
KW   Cytoplasm
KW   Diaminopimelate biosynthesis
KW   Lysine biosynthesis
KW   Repeat
KW   Transferase
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GO   GO:0008666; F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO   GO:0019877; P:diaminopimelate biosynthetic process
GO   GO:0009089; P:lysine biosynthetic process via diaminopimelate
GO   GO:0005737; C:cytoplasm
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FT   From: DAPD_UNKP (P56220)
FT   BINDING         104
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         141
FT                   /ligand="substrate"
FT   Condition: D
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Size: 271-289;
Related: None;
Template: P56220; P0A9D8; Q8X8Y7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: There is a second family of DapD (see MF_02122).
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# Revision 1.25 2023/06/01
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