AC   MF_00812;
DC   Protein; auto
TR   HAMAP; MF_00812; -; 1; level=0
XX
Names: Thiopur_methtran
XX
ID   TPMT
DE   RecName: Full=Thiopurine S-methyltransferase;
DE            EC=2.1.1.67;
DE   AltName: Full=Thiopurine methyltransferase;
GN   Name=tpm;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-
CC         homocysteine + a thiopurine S-methylether.; EC=2.1.1.67;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TPMT family.
XX
DR   Pfam; PF05724; TPMT; 1; trigger=no
DR   PIRSF; PIRSF023956; Thiopurine_S-methyltransferase; 1; trigger=no
DR   NCBIfam; TIGR03840; TMPT_Se_Te; 1; trigger=no
DR   PROSITE; PS51585; SAM_MT_TPMT; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0008119; F:thiopurine S-methyltransferase activity
GO   GO:0005737; C:cytoplasm
XX
FT   From: TPMT_VIBCH (Q9KSN0)
FT   BINDING         11
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: W
FT   BINDING         46
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [LM]
FT   BINDING         67
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
FT   BINDING         122
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
XX
Size: 213-235;
Related: None;
Template: O86262;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.24 2023/06/01
//