AC   MF_00823;
DC   Protein; auto
TR   HAMAP; MF_00823; -; 1; level=0
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Names: AcetylCoA_CT_alpha
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ID   ACCA
DE   RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha;
DE            Short=ACCase subunit alpha;
DE            Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha;
DE            EC=2.1.3.15;
GN   Name=accA;
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CC   -!- FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex.
CC       First, biotin carboxylase catalyzes the carboxylation of biotin on its
CC       carrier protein (BCCP) and then the CO(2) group is transferred by the
CC       carboxyltransferase to acetyl-CoA to form malonyl-CoA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-
CC         CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728,
CC         Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15;
CC   -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC       acetyl-CoA: step 1/1.
CC   -!- SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of biotin
CC       carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two
CC       subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta
CC       (AccD).
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
case not <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the AccA family.
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DR   Pfam; PF03255; ACCA; 1; trigger=no
DR   Pfam; PF01039; Carboxyl_trans; 1; trigger=no
DR   Pfam; PF00378; ECH; 1; trigger=no
DR   PRINTS; PR01069; ACCCTRFRASEA; 1; trigger=no
DR   NCBIfam; TIGR00513; AccA; 1; trigger=no
DR   PROSITE; PS50989; COA_CT_CTER; 1; trigger=yes
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KW   ATP-binding
case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Nucleotide-binding
KW   Transferase
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GO   GO:0016743; F:carboxyl- or carbamoyltransferase activity
GO   GO:0006633; P:fatty acid biosynthetic process
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
case not <OG:Chloroplast>
GO   GO:0005737; C:cytoplasm
end case
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FT   None
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Size: 255-368;
Related: None;
Template: P0ABD5;
Scope:
 Bacteria
 Plastid
Fusion:
 Nter: MF_01395 (accD)
 Cter: None
Duplicate: in BACC1
Plasmid: None
Comments: A few Bacillota encode a fusion between accD and accA (CLOTE,
 EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN,
 SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form
 in their plastids and the eukaryotic form in the cytoplasm. The
 prokaryotic form is longer than the one found in bacteria. The grass
 family (Poaceae) have only the eukaryotic form in both locations. The
 eukaryotic form consists of a single large protein in which are fused all
 4 subunits that are separate in prokaryotes.
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# Revision 1.29 2023/06/01
//