AC   MF_00838;
DC   Protein; auto
TR   HAMAP; MF_00838; -; 1; level=0
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Names: DacB
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ID   DACB
DE   RecName: Full=Diadenylate cyclase;
DE            Short=DAC;
DE            EC=2.7.7.85;
DE   AltName: Full=Cyclic-di-AMP synthase;
DE            Short=c-di-AMP synthase;
GN   Name=dacB;
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CC   -!- FUNCTION: Catalyzes the condensation of 2 ATP molecules into cyclic di-
CC       AMP (c-di-AMP), a second messenger used to regulate differing processes
CC       in different bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
CC   -!- SUBUNIT: Probably oligomerizes.
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the adenylate cyclase family. DacB/CdaS
CC       subfamily.
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DR   PROSITE; PS51794; DAC; 1; trigger=yes
DR   Pfam; PF02457; DisA_N; 1; trigger=no
DR   PIRSF; PIRSF004793; UCP004793; 1; trigger=no
DR   General; Transmembrane; -; 0-3; trigger=yes
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KW   ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Membrane
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0004016; F:adenylate cyclase activity
GO   GO:0005524; F:ATP binding
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0019932; P:second-messenger-mediated signaling
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FT   None
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Size: 197-257;
Related: MF_00840; MF_01438; MF_01499;
Template: Q8Y5E4; Q45589;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Not found in all bacterial lineages, in 2 characterized Bacillus
 is expressed in spores, and has an alternative name. The dacB gene name
 was suggested in PMID 23812326.
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# Revision 1.6 2019/11/18
//