AC   MF_00840;
DC   Protein; auto
TR   HAMAP; MF_00840; -; 1; level=0
XX
Names: DacZ
XX
ID   DACZ
DE   RecName: Full=Diadenylate cyclase;
DE            Short=DAC;
DE            EC=2.7.7.85;
DE   AltName: Full=Cyclic-di-AMP synthase;
DE            Short=c-di-AMP synthase;
GN   Name=dacZ;
XX
CC   -!- FUNCTION: Diadenylate cyclase that catalyzes the condensation of 2 ATP
CC       molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger
CC       for intracellular signal transduction involved in the control of
CC       important regulatory processes such as osmoregulation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- SIMILARITY: Belongs to the adenylate cyclase family. DacZ subfamily.
XX
DR   PROSITE; PS51794; DAC; 1; trigger=yes
DR   Pfam; PF02457; DisA_N; 1; trigger=no
DR   PIRSF; PIRSF019073; UCP019073; 1; trigger=no
XX
KW   ATP-binding
KW   Manganese
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
XX
GO   GO:0004016; F:adenylate cyclase activity
GO   GO:0005524; F:ATP binding
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0019932; P:second-messenger-mediated signaling
XX
FT   None
XX
Size: 239-312;
Related: MF_00838; MF_01438; MF_01499;
Template: Q58408; D4GZM5;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Found in some Euryarchaeota, there are also possible members in
 some bacteria but they are not currently annotated as such. The gene name
 was given in PMID 23812326.
XX
# Revision 1.6 2019/11/18
//