AC   MF_00841;
DC   Protein; auto
TR   HAMAP; MF_00841; -; 1; level=0
XX
Names: Gtf3
XX
ID   GTF3
DE   RecName: Full=Glucosyltransferase 3;
DE            EC=2.4.1.-;
GN   Name=gtf3;
XX
case <OC:Streptococcus>
CC   -!- FUNCTION: Required for polymorphic O-glycosylation of the serine-rich
CC       repeat protein in this bacteria. Catalyzes the second step in
CC       glycosylation by transferring glucose from UDP-glucose to the terminal
CC       GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-
CC       [protein] resulting from the first glycosylation step.
else
CC   -!- FUNCTION: Required for polymorphic O-glycosylation of the serine-rich
CC       repeat protein in this bacteria. Catalyzes the second step in
CC       glycosylation by transferring a sugar from a UDP-activated sugar to the
CC       terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-
CC       seryl-[protein] resulting from the first glycosylation step.
end case
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBUNIT: Homotetramer; a dimer of dimers.
CC   -!- DOMAIN: Dimerizes via the C-terminus; dimerization is required for
CC       tetramer formation. Binds protein substrate via an exposed loop in the
CC       N-terminus.
CC   -!- SIMILARITY: Belongs to the Gtf3 glucosyltransferase family.
XX
DR   PIRSF; PIRSF007023; UDP-Galf_transf; 1; trigger=no
XX
KW   Glycosyltransferase
KW   Nucleotide-binding
KW   Transferase
XX
case <OC:Streptococcus>
GO   GO:0035251; F:UDP-glucosyltransferase activity
else
GO   GO:0008194; F:UDP-glycosyltransferase activity
end case
XX
FT   From: GTF3_STRPA (B5A7L9)
FT   BINDING         244..249
FT                   /ligand="UDP"
FT                   /ligand_id="ChEBI:CHEBI:58223"
FT   Condition: [NPS]-[FHY]-K-x-[AGS]-[AIST]
FT   BINDING         16
FT                   /ligand="UDP"
FT                   /ligand_id="ChEBI:CHEBI:58223"
FT   Optional; Condition: T
FT   BINDING         179
FT                   /ligand="UDP"
FT                   /ligand_id="ChEBI:CHEBI:58223"
FT   Condition: [KRT]
XX
Size: 309-345;
Related: None;
Template: B5A7L9; A0A0H2UR93; A0A0M3KKZ0; B3XPQ7; F8KEJ1;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/01/13
//