AC   MF_00842;
DC   Protein; auto
TR   HAMAP; MF_00842; -; 1; level=0
XX
Names: OmpA
XX
ID   OMPA
DE   RecName: Full=Outer membrane protein A;
DE   AltName: Full=Outer membrane porin A;
GN   Name=ompA;
XX
CC   -!- FUNCTION: With TolR probably plays a role in maintaining the position
CC       of the peptidoglycan cell wall in the periplasm. Acts as a porin with
CC       low permeability that allows slow penetration of small solutes; an
CC       internal gate slows down solute passage.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
CC   -!- FUNCTION: Required for conjugation with F-type plasmids; probably
CC       serves as the mating receptor on recipient cells.
end case
CC   -!- SUBUNIT: Monomer and homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- DOMAIN: The extracellular loops are most variable in sequence, and in
CC       some bacteria confer sensitivity to phage and/or colicins.
CC   -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC       OmpA family.
XX
DR   PROSITE; PS01068; OMPA_1; 1; trigger=no
DR   PROSITE; PS51123; OMPA_2; 1; trigger=yes
DR   Pfam; PF00691; OmpA; 1; trigger=no
DR   Pfam; PF01389; OmpA_membrane; 1; trigger=no
DR   PRINTS; PR01021; OMPADOMAIN; 1; trigger=no
DR   PRINTS; PR01022; OUTRMMBRANEA; 1; trigger=no
DR   General; Signal; -; 0-1; trigger=yes
XX
KW   Cell outer membrane
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
KW   Conjugation
end case
case <FTTag:Disulfide>
KW   Disulfide bond
end case
KW   Ion transport
KW   Membrane
KW   Porin
KW   Transmembrane
KW   Transmembrane beta strand
KW   Transport
XX
GO   GO:0009279; C:cell outer membrane
GO   GO:0034220; P:monoatomic ion transmembrane transport
GO   GO:0015288; F:porin activity
XX
FT   From: OMPA_ECOLI (P0A910)
FT   TRANSMEM        27..37
FT                   /note="Beta stranded"
FT   TRANSMEM        55..66
FT                   /note="Beta stranded"
FT   TRANSMEM        70..78
FT                   /note="Beta stranded"
FT   TRANSMEM        96..107
FT                   /note="Beta stranded"
FT   TRANSMEM        112..120
FT                   /note="Beta stranded"
FT   TRANSMEM        142..151
FT                   /note="Beta stranded"
FT   TRANSMEM        156..163
FT                   /note="Beta stranded"
FT   TRANSMEM        182..190
FT                   /note="Beta stranded"
FT   SITE            73
FT                   /note="Part of salt bridge gating mechanism"
FT   Condition: E
FT   SITE            159
FT                   /note="Part of salt bridge gating mechanism"
FT   Condition: R
FT   DISULFID        311..323
FT   Tag: Disulfide; Optional; Condition: C-x*-C
XX
Size: 320-390;
Related: None;
Template: P0A910;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/02/07
//