AC   MF_00843;
DC   Protein; auto
TR   HAMAP; MF_00843; -; 1; level=0
XX
Names: Lpp
XX
ID   LPP
DE   RecName: Full=Major outer membrane lipoprotein Lpp;
case <OC:Escherichia> or <OC:Yersinia> or <OC:Salmonella>
DE   AltName: Full=Braun lipoprotein;
DE            Short=BLP;
end case
case <OC:Escherichia> or <OC:Salmonella>
DE   AltName: Full=Murein lipoprotein;
end case
DE   Flags: Precursor;
GN   Name=lpp;
XX
CC   -!- FUNCTION: A highly abundant outer membrane lipoprotein that controls
CC       the distance between the inner and outer membranes. The only protein
CC       known to be covalently linked to the peptidoglycan network (PGN). Also
CC       non-covalently binds the PGN. The link between the cell outer membrane
CC       and PGN contributes to maintenance of the structural and functional
CC       integrity of the cell envelope, and maintains the correct distance
CC       between the PGN and the outer membrane.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor; Periplasmic
CC       side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its
CC       lipidated N-terminus to the inner leaflet of the outer membrane.
CC       Attached to the peptidoglycan network (PGN) via its C-terminus.
CC   -!- SIMILARITY: Belongs to the Lpp family.
XX
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1; trigger=yes
DR   Pfam; PF04728; LPP; 1; trigger=no
DR   PIRSF; PIRSF002855; Murein-lipoprotein; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
XX
KW   Cell outer membrane
KW   Cell wall
KW   Lipoprotein
KW   Membrane
KW   Palmitate
KW   Peptidoglycan-anchor
KW   Repeat
KW   Secreted
XX
GO   GO:0009279; C:cell outer membrane
GO   GO:0008289; F:lipid binding
GO   GO:0042834; F:peptidoglycan binding
GO   GO:0030258; P:lipid modification
GO   GO:0043580; P:periplasmic space organization
XX
FT   From: LPP_ECOLI (P69776)
FT   REPEAT          24..34
FT   REPEAT          38..48
FT   MOD_RES         78
FT                   /note="N6-murein peptidoglycan lysine"
FT   Condition: K
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT   Condition: C
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT   Condition: C
XX
Size: 62-119;
Related: None;
Template: P69776;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Quite similar to YqhH, but it has a C-terminal Glu residue.
 Duplicated in Salmonella.
XX
# Version: 7
# Last updated date: 2023-01-26
# Created date: 2019-05-21
//