AC   MF_00844;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_00844_B; -; 1; level=0
c?   <OC:Archaea>
TR   HAMAP; MF_00844_A; -; 1; level=0
XX
Names: RqcH
XX
ID   RQCH
case <OC:Bacteria>
DE   RecName: Full=Rqc2 homolog RqcH;
DE            Short=RqcH;
else case <OC:Archaea>
DE   RecName: Full=Archaeal Rqc2 homolog aRqcH;
DE            Short=aRqcH;
end case
GN   Name=rqcH;
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Key component of the ribosome quality control system (RQC), a
CC       ribosome-associated complex that mediates the extraction of
CC       incompletely synthesized nascent chains from stalled ribosomes and
CC       their subsequent degradation. RqcH recruits Ala-charged tRNA, and with
CC       RqcP directs the elongation of stalled nascent chains on 50S ribosomal
CC       subunits, leading to non-templated C-terminal alanine extensions (Ala
CC       tail). The Ala tail promotes nascent chain degradation. May add between
CC       1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits. Binds to RqcP.
else case <OC:Archaea>
CC   -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC       May mediate the addition of alanine residues (Ala tailing) to
CC       incompletely synthesized nascent chains from stalled ribosomes, leading
CC       to their degradation.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
end case
CC   -!- SIMILARITY: Belongs to the NEMF family.
XX
DR   Pfam; PF05670; NFACT-R_1; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=strict
XX
case <Feature:coiled>
KW   Coiled coil
end case
KW   Protein biosynthesis
KW   RNA-binding
KW   rRNA-binding
KW   tRNA-binding
XX
GO   GO:0019843; F:rRNA binding
GO   GO:0000049; F:tRNA binding
GO   GO:0043023; F:ribosomal large subunit binding
GO   GO:0072344; P:rescue of stalled ribosome
XX
FT   None
XX
# Version: 6
# Last updated date: 2024-09-02
# Created date: 2019-07-29
case <OC:Bacteria>
Size: 500-740;
end case
case <OC:Archaea>
Size: 560-800;
end case
Related: None;
Template: O34693; Q59020;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
//