AC   MF_00846;
DC   Protein; auto
TR   HAMAP; MF_00846; -; 1; level=0
XX
Names: VmlR
XX
ID   VMLR
DE   RecName: Full=Ribosome protection protein VmlR;
GN   Name=vmlR;
XX
CC   -!- FUNCTION: Recognizes and binds in the vacant E-site of ribosomes
CC       stalled by some peptidyltransferase center (PTC)-targeting antibiotics.
CC       Makes contact with the PTC and both ribosomal subunits. Induces
CC       conformational changes in the P-site, which allows it to dislodge the
CC       antibiotic from its PTC binding site.
CC   -!- SUBUNIT: Binds within the E-site of the 70S ribosome, where it contacts
CC       ribosomal proteins of the large and small subunit, the 16 and 23S rRNAs
CC       and the acceptor arm of the P-site tRNA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Does not stably associate with
CC       ribosomes.
CC   -!- DOMAIN: The antibiotic resistance domain (ARD) is packed between the
CC       23S rRNA and the acceptor arm of the P-site tRNA and inserts into the
CC       peptidyltransferase center (PTC). The C-terminal extension (CTE)
CC       contacts the small ribosomal subunit, positioned in the Shine-Dalgarno-
CC       anti-Shine-Dalgarno cavity.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC       ARE2 subfamily.
XX
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2; trigger=no
DR   Pfam; PF00005; ABC_tran; 3; trigger=no
DR   Pfam; PF12848; ABC_tran_Xtn; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
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KW   Antibiotic resistance
KW   ATP-binding
KW   Cytoplasm
KW   Nucleotide-binding
KW   Repeat
KW   RNA-binding
KW   rRNA-binding
KW   tRNA-binding
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GO   GO:0005524; F:ATP binding
GO   GO:0005737; C:cytoplasm
GO   GO:0072344; P:rescue of stalled ribosome
GO   GO:0019843; F:rRNA binding
GO   GO:0000049; F:tRNA binding
XX
FT   From: VMLR_BACSU (P39115)
FT   DOMAIN          5..200
FT                   /note="ABC transporter 1"
FT   DOMAIN          292..504
FT                   /note="ABC transporter 2"
FT   BINDING         37..44
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT   Condition: G-x-N-G-[ATV]-G-K-[ST]
FT   BINDING         324..331
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT   Condition: G-x-N-G-[SICA]-G-K-[TS]
FT   REGION          183..289
FT                   /note="Antibiotic resistance domain (ARD)"
FT   REGION          483..547
FT                   /note="C-terminal extension (CTE)"
XX
Size: 530-560;
Related: None;
Template: P39115;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Bacillota
 Bacteria; Mycoplasmatota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/02/17
//