AC   MF_00847;
DC   Protein; auto
TR   HAMAP; MF_00847; -; 1; level=0
XX
Names: EttA
XX
ID   ETTA
DE   RecName: Full=Energy-dependent translational throttle protein EttA;
DE            EC=3.6.1.-;
DE   AltName: Full=Translational regulatory factor EttA;
GN   Name=ettA;
XX
CC   -!- FUNCTION: A translation factor that gates the progression of the 70S
CC       ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site)
CC       into the translation elongation cycle by using a mechanism sensitive to
CC       the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates
CC       the state of the translating ribosome during subunit translocation. ATP
CC       hydrolysis probably frees it from the ribosome, which can enter the
CC       elongation phase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- SUBUNIT: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and
CC       S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Associates with ribosomes and
CC       polysomes.
CC   -!- DOMAIN: The arm domain is inserted in the first ABC transporter domain.
CC       Probably contacts ribosomal protein L1.
CC   -!- DOMAIN: The P-site tRNA interaction motif (PtIM domain) probably
CC       interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC       Translational throttle EttA subfamily.
XX
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1; trigger=no
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2; trigger=no
DR   Pfam; PF00005; ABC_tran; 2; trigger=no
DR   Pfam; PF12848; ABC_tran_Xtn; 1; trigger=no
DR   NCBIfam; TIGR03719; ABC_ABC_ChvD; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   Hydrolase
KW   Nucleotide-binding
KW   Protein biosynthesis
KW   Repeat
KW   RNA-binding
KW   rRNA-binding
KW   Translation regulation
KW   tRNA-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0016887; F:ATP hydrolysis activity
GO   GO:0005737; C:cytoplasm
GO   GO:0019843; F:rRNA binding
GO   GO:0000049; F:tRNA binding
GO   GO:0043022; F:ribosome binding
GO   GO:0045900; P:negative regulation of translational elongation
XX
FT   From: ETTA_ECOLI (P0A9W3)
FT   DOMAIN          6..259
FT                   /note="ABC transporter 1"
FT   DOMAIN          324..550
FT                   /note="ABC transporter 2"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT   Condition: G-x-N-G-[ATV]-G-K-[ST]
FT   BINDING         356..363
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT   Condition: G-x-N-G-[SICAV]-G-K-[TS]
FT   REGION          95..139
FT                   /note="Arm"
FT   REGION          242..322
FT                   /note="PtIM"
XX
Size: 544-646;
Related: None;
Template: P0A9W3;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/06/01
//